Ozone Injections: Harnessing the Power of Ozone for Pain Relief and Regenerative Medicine

Ozone Injections: Harnessing the Power of Ozone for Pain Relief and Regenerative Medicine

By Vitality Integrative Wellness

A syringe being filled for an ozone injection. Ozone injections aid in pain relief. ​Ozone, or O3, is a naturally occurring gas molecule composed of three oxygen atoms. The 3 molecules that makeup ozone are much less stable than 2 molecules of oxygen. This instability causes that 3rd molecule to try to neutralize quickly and the easiest way to do this is to bind with fats and amino acids. When ozone binds to fats and amino acids, it improves the utilization of oxygen in the cell, improving the functionality of the cell.

Understanding Ozone/Prolozone Therapy

Ozone therapy is an innovative treatment that utilizes ozone gas to promote healing and alleviate pain. There are a few methods of administering O3, including injections to target specific areas of the body.

Ozone contains many potent antimicrobial properties so, as ozone gas is injected into the body, it interacts with biological substances and triggers several beneficial responses. These properties help combat bacteria, viruses, and fungi, which cause infections that contribute to pain and inflammation.

What Does Ozone/Prolozone Therapy Treat?

As the ozone gas is directly injected into the affected area, it reduces inflammation, relieves muscle tension, and improves blood circulation, which leads to improved mobility and functionality through tissue repair and regeneration.

A man with back pain holding his lower back.

Ozone injections have been shown to provide pain relief for back and neck pain, joint disorders, and chronic inflammation. By targeting the underlying causes of pain and promoting healing, ozone therapy can help alleviate pain and improve the quality of life for those who struggle with these conditions.

What is an Ozone/Prolozone Injection?

Ozone injections are becoming increasingly popular as a non-surgical alternative for pain relief and regenerative medicine. Prolozone is a liquid injection of procaine, vitamins, and minerals into painful areas of the body followed by an injection of ozone. The therapy has been used for more than 40 years as an injection technique used to stimulate the body’s natural healing response. It has positive effects on auto-immune disease, cancer, arthritis, infectious diseases, inflammatory diseases, chronic and acute pain, and cardiovascular disease. The therapy reduces inflammation and restores circulation and tissues get what they need to heal. 

What is the Process?

A patient experiencing elbow pain about to receive an ozone injection to aid with healing and pain management. Ozone injections involve a specific procedure that includes the administration technique and the equipment used. During ozone injections, a qualified healthcare professional uses a fine needle to deliver ozone gas directly into the targeted area. The ozone gas is typically mixed with a small amount of oxygen to achieve the desired concentration. The injection may be performed intramuscularly, subcutaneously, or intra-articularly, depending on the specific condition being treated.

It is common to experience temporary local discomfort or swelling at the injection site, mild headache, or fatigue.

Due to the specialized nature of ozone therapy, it is crucial to seek a healthcare professional experienced in administering ozone injections. They will conduct a thorough assessment of your medical history and needs to determine the suitability of ozone therapy for the specific condition being treated.

Known Benefits of Medical Ozone Therapy:

  1. Natural Detoxifier
    1. Ozone is negatively charged so it binds with positively charged toxins and neutralizes them, making it easier for the body to remove them – much like an air purifier or a filter in a swimming pool.
  2. Naturally Antiviral, Antibiotic, Anti-fungal, and Antiparasitic
    1. As ozone enters the toxins it explodes the cell walls and eliminates them.
  3. Boosts the Immune System
    1. The immune system naturally produces an amount of ozone to defend itself against bacteria and invasive cells and to heal the body. By having additional ozone targeted to an affected area, the immune system gets a boost of healing power.
  4. Reduces Inflammation
    1. There are small proteins called cytokines that control the growth and activity of cells and blood vessels which help with cell damage repair, cell replication, and managing the inflammatory response.
    2. Ozone stimulates Anti-inflammatory responses which is why it is highly effective for those who suffer from arthritis conditions!
  5. Oxygen is a Cell’s Source of Energy
    1. Ozone helps to increase the amount of oxygen in the cell. The more oxygen a cell has, the more allowance the cell gets to utilize glucose which improves metabolism.

What Patients are Saying:

“My knee was [swollen], I was in pain, and I had just a few weeks until a big competition. Vitality Integrative Wellness recommended Ozone multiple times before I went. It definitely was sore initially but within a day or two, I felt relief. I was blown away by how quickly it worked! I didn’t have to take all this time off and rest… within days I felt way better. Within 2 weeks my knee was totally healed.” - Carly, High-level Cross-Fit Athlete


Chronic pain exists in joints because of their particular function. They have a low blood supply compared to muscles or organs. This makes them very susceptible to decreased oxygen utilization. 

Add to that injury or damage to the joint which will increase inflammation and swelling. All of this leads to a localized decrease in oxygen utilization. A vicious cycle ensues due to increased free radical damage which just makes the oxygen utilization decrease even more. 

Over time this results in an inability of stem cells to be able to heal the damaged tissue.
Prolozone breaks this cycle- repolarizes cell membrane and increases circulation. The vitamins and minerals assist with oxidation. Ozone improves oxygen utilization and interacts with amino acids and lipids (fats) to form peroxides. 

These therapies can be combined with other regenerative therapies or as stand-alone therapies for backs, necks, knees, elbows, shoulders, and other joint or muscle-related conditions. 

Reach out to schedule a consultation with us at Vitality Integrative Wellness to determine if ozone therapy is suitable for you and get started on your healing journey today.