What is A2M?
A2M, or Alpha 2 Macroglobulin, is a powerful protein found in blood plasma. It combats inflammation by inhibiting harmful proteases and cytokines, which are key drivers of inflammation, joint pain, and arthritis.
Chronic inflammation can cause significant pain, fatigue, and joint damage. While NSAIDs (Nonsteroidal anti-inflammatory drugs) are commonly prescribed, they only mask the symptoms and don't address the root cause. A2M molecules directly target and neutralize harmful proteases, promoting joint health and reducing pain effectively.
A2M proteins effectively capture and neutralize a wide range of harmful proteases. These captured proteases are then transported to the liver and eliminated from the body through urination, feces, or sweat, significantly reducing inflammation and associated pain.
Joints often experience high levels of protease activity, leading to inflammatory cascades that cause osteoarthritis. Without treatment, symptoms can worsen, resulting in severe joint pain. While natural A2M in your body attempts to combat this inflammation, it may be insufficient during a cascade. The providers at Vitality Integrative Wellness, explains, “Alpha-2 macroglobulin circulates through the bloodstream in low concentrations. If protease levels exceed what A2M can neutralize, joint degeneration continues, leading to arthritis.”
What is the solution?
Research has shown that when A2M is extracted from the blood and administered in concentrated doses, it can halt and sometimes reverse arthritis effects. While still in the research phase, clinical results are promising, with patients experiencing significant recovery. Vitality providers noted, “After two to three weeks post-treatment, one patient reported her back stopped going out, numbness in her leg ceased, and she regained feeling in her toes. Three months later, she could run for the first time in three years and perform activities without restriction, with most symptoms resolved after 90 days.”
What’s the Process?
A2M treatment stands out from other regenerative therapies as a non-surgical option. Utilizing Alpha 2 Macroglobulin that comes from the patient's own blood, not donor cells or stem cells. The process involves drawing the patient's blood, filtering out A2M molecules using sophisticated equipment, and injecting the concentrated A2M directly into the affected joint. Patients should rest and recover for a few weeks following the injection.
Side effects of A2M injections can include pain, swelling, bruising, or inflammation at the injection site, typically subsiding within a few days. As these side- effects diminish, patients often experience pain relief and improved joint function. Some report active healing of the treated joint. Increased fatigue may occur as the body heals, which is a normal part of the recovery process.
Vitality offers a variety of supportive services to maximize the treatment’s effectiveness. This includes at-home rehabilitative exercises, chiropractic adjustments, and a series of ozone shots that provide energy to the joint to aid in recovery time.
A single A2M injection can halt and sometimes completely stop arthritis progression. A2M treatment targets the root cause of arthritis. Providers at Vitality says “If you suffer from osteoarthritis it’s better to do A2M first [rather than donor cell injections]. Donor cells are like adding fertilizer to your lawn. You're going to get a greener lawn. You're going to get more growth, but if your lawn is loaded with weeds and dandelions (osteoarthritis) then, you're just fertilizing all of the garbage as well. So A2M is better for an arthritic patient because we can go in there and we can pull the weeds out of the garden.”
By targeting only the negative proteases, the treatment can remove the source of the arthritis. Discussing A2M’s effectiveness as opposed to other treatments, Vitality providers said, “We're also targeting more of the arthritis. Instead of just relieving pain or trying to replace degenerated tissue or increase its health, we're actually improving the structure [of the tissue that’s present].”
